Lilo & Stitch

Lilo

Maia Kealoha

↔ Nani

Nani

Sydney Agudong

↔ Lilo

Stitch (voice)

Chris Sanders

Jumba

Zach Galifianakis

Pleakley

Billy Magnussen

Nani Pelekai, the older sister of Lilo and her legal guardian. She is described as "intelligent, overachieving, athletic, Type A" and a "straight-A student" who has been feeling the increasing pressures of having to take care of Lilo, causing issues with her and Lilo's social worker, with child protective services threatening to separate the Pelekai sisters and put Lilo into foster care.

Sydney Elizebeth Agudong

Galifianakis also physically portrays "Marcus", Jumba's human disguise based on a hotel employee with that name.

Magnussen also portrays Pleakley's human disguise, which is based on an unnamed human who was interacting with the real Marcus when Jumba and Pleakley copied their appearances.

Cobra Bubbles, a CIA agent sent to capture Stitch. While he is not the Pelekais' social worker in this film, he goes undercover as a social director after finding out about Stitch being with the Pelekais.

Courtney B. Vance

Tūtū, a Native Hawaiian in her 70s who is the long-time neighbor of the Pelekais and the grandmother of David Kawena. She is described as "a warm, quick-witted woman who speaks with a local Pidgin accent". She is original to this film. Hill previously voiced Mrs. Hasagawa in the original film and Lilo & Stitch: The Series. In Hawaiian culture, the word "tutu" is commonly used to refer to grandparents.

Amy Hill

Mrs. Kekoa, a social worker who is "a practical, by-the-book kind and patient woman who checks in regularly with Nani", but is nevertheless aware of Nani's struggles to keep up with her duties. Carrere previously voiced Nani in Lilo & Stitch animated media.

Tia Carrere

David Kawena, a fire performer and lifeguard who is a loyal friend and neighbor to Lilo and Nani. He performs the "fire knife dance" at the lūʻau where he and Nani work at. Kahiau Machado was originally cast in the role, but he was recast shortly thereafter due to his prior usage of a racial slur.

Kaipo Dudoit

the voice of the Grand Councilwoman, the grey alien leader of the United Galactic Federation and its council who orders Jumba and Pleakley to capture Stitch after his escape.